lack of association between interleukin 12 c(-1188)a polymorphism and irritable bowel syndrome
نویسندگان
چکیده
irritable bowel syndrome (ibs) is a functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. this study was performed to investigate the important role of interleukin-12 (il-12) in intestinal inflammation. for this study seventy one patients with ibs and 140 controls were investigated. the allele and genotype frequencies of il-12 c(-1188)a were determined using polymerase chain reaction with sequence-specific primers. the allele a was more common that the allele c in both groups of patients and controls. there was not any significant difference on il-12 alleles and genotypes between patients and controls. the aa genotype was the most common genotypes, which was seen in 57.4% of the patients and 51.4% of the controls (p=0.53). although frequency of the cc genotype in the control group was lower than the patient group, this difference was not significant (5.7% vs. 11.5%, respectively, p=0.16). considering the lack of association between il-12 c(-1188)a polymorphism and ibs, this cytokine gene polymorphism may not have significant role in the pathophysiology of disease.
منابع مشابه
Lack of Association between Interleukin 12 C(-1188)A Polymorphism and Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. This study was performed to investigate the important role of interleukin-12 (IL-12) in intestinal inflammation. For this study seventy one patients with IBS and 140 controls were investigated. The allele and genotype frequencies of IL-12 C(-1188)A were d...
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عنوان ژورنال:
avicenna journal of medical biotechnologyجلد ۳، شماره ۱، صفحات ۴۵-۴۸
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